CHBC Faculty Publications

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Author: Shi, Wei

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TitlePublication NamePub. TypeYear
Ring Expansion Leads to a More Potent Analogue of Ipomoeassin FJournal of Organic ChemistryJournal Article2020
Ipomoeassin F binds Sec61a to inhibit protein translocation.ChemRxivPreprint2019
Ipomoeassin F Binds Sec61 alpha to Inhibit Protein TranslocationJournal of the American Chemical SocietyJournal Article2019
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological SpaceACS Central ScienceJournal Article2018
Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP)Antiviral ResearchJournal Article2018
New insights into structure-activity relationship of ipomoeassin F from its bioisosteric 5-oxa/aza analoguesEuropean journal of Medicinal ChemistryJournal Article2018
Unique natural macrocycles of ipomoeassin glycoresins with potent cytotoxicityAbstracts of Papers, 253rd ACS National Meeting and Exposition, San Francisco, CA, United States, April 2-6, 2017Abstract2017
Bioisosteric 5-oxa/aza analogues of ipomoeassin F uncover an H-bonding activity cliff and moreAbstracts of Papers, 254th ACS National Meeting and Exposition, Washington, DC, United States, August 20-24, 2017Abstract2017
Late-stage modification of tigloyl moiety to ipomoeassin F to enable SAR studies of the natural productAbstracts of Papers, 254th ACS National Meeting and Exposition, Washington, DC, United States, August 20-24, 2017Abstract2017
Design, synthesis and biological evaluation of fucose-truncated monosaccharide analogues of ipomoeassin FAbstracts of Papers, 254th ACS National Meeting and Exposition, Washington, DC, United States, August 20-24, 2017Abstract2017
Synthesis of ipomoeassin F analogs with a tail modified aglyconeAbstracts of Papers, 254th ACS National Meeting and Exposition, Washington, DC, United States, August 20-24, 2017Abstract2017
Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and AngiogenesisACS Chemical BiologyJournal Article2017
Design, synthesis and biological evaluation of fucose-truncated monosaccharide analogues of ipomoeassin FBioorganic and Medicinal Chemistry LettersJournal Article2017
Synergistic Contribution of Tiglate and Cinnamate to Cytotoxicity of Ipomoeassin FJournal of Organic ChemistryJournal Article2017
Establishing a route for the synthesis of ipomoeassin F analogs containing a modified aglycone.Abstracts, 28th International Carbohydrate Symposium, New Orleans, LA, United States, July 17-21, 2016Abstract2016
Exploring the mode of action of ipomoeassin natural glycoresins.Abstracts, 28th International Carbohydrate Symposium, New Orleans, LA, United States, July 17-21, 2016Abstract2016
Late-stage modification of C-3 tigoyl moiety of ipomoeassin F to enable SAR studies.Abstracts, 28th International Carbohydrate Symposium, New Orleans, LA, United States, July 17-21, 2016Abstract2016
Understanding the functional mechanism of ipomoeassin natural glycoresins.Abstracts, 28th International Carbohydrate Symposium, New Orleans, LA, United States, July 17-21, 2016Abstract2016
Divergence of Antiangiogenic Activity and Hepatotoxicity of Different Stereoisomers of ItraconazoleClinical Cancer ResearchJournal Article2016
Revealing the Pharmacophore of Ipomoeassin F through Molecular EditingOrganic LettersJournal Article2016
Cytotoxic natural product Ipomoeassin F: SAR-guided probe design for target identificationAbstracts of Papers, 250th ACS National Meeting and Exposition, Boston, MA, United States, August 16-20, 2015Abstract2015
Total synthesis and biological evaluation of the C-11 epimer of ipomoeassin FAbstracts of Papers, 250th ACS National Meeting and Exposition, Boston, MA, United States, August 16-20, 2015Abstract2015
Total synthesis and SAR study of ipomoeassin FAbstracts of Papers, 250th ACS National Meeting and Exposition, Boston, MA, United States, August 16-20, 2015Abstract2015
Chemical proteomics to the development of natural glycoconjugates towards novel anticancer agentsAbstracts, 50th Midwest Regional Meeting of the American Chemical Society, St.Joseph, MO, United States, October 21-24, 2015Abstract2015
Total Synthesis and Biological Evaluation of Ipomoeassin F and Its Unnatural 11R-EpimerJournal of Organic ChemistryJournal Article2015
Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cellsProceedings of the National Academy of Sciences of the United States of AmericaJournal Article2015