CHBC Faculty Publications

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Author: Shi, Wei

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TitlePublication NamePub. TypeYear
Ipomoeassin F binds Sec61a to inhibit protein translocation.ChemRxivJournal Article2019
Ipomoeassin F Binds Sec61 alpha to Inhibit Protein TranslocationJournal of the American Chemical SocietyJournal Article2019
New insights into structure-activity relationship of ipomoeassin F from its bioisosteric 5-oxa/aza analoguesEuropean Journal of Medicinal ChemistryJournal Article2018
Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP)Antiviral ResearchJournal Article2018
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological SpaceACS Central ScienceJournal Article2018
Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and AngiogenesisACS Chemical BiologyJournal Article2017
Design, synthesis and biological evaluation of fucose-truncated monosaccharide analogues of ipomoeassin FBioorganic and Medicinal Chemistry LettersJournal Article2017
Unique natural macrocycles of ipomoeassin glycoresins with potent cytotoxicityAbstracts of Papers of the American Chemical SocietyAbstract2017
Design, synthesis and biological evaluation of fucose-truncated monosaccharide analogues of ipomoeassin FAbstracts of Papers of the American Chemical SocietyAbstract2017
Synthesis of ipomoeassin F analogs with a tail modified aglyconeAbstracts of Papers of the American Chemical SocietyAbstract2017
Late-stage modification of tigloyl moiety to ipomoeassin F to enable SAR studies of the natural productAbstracts of Papers of the American Chemical SocietyAbstract2017
Bioisosteric 5-oxa/aza analogues of ipomoeassin F uncover an H-bonding activity cliff and moreAbstracts of Papers of the American Chemical SocietyAbstract2017
Synergistic Contribution of Tiglate and Cinnamate to Cytotoxicity of Ipomoeassin FJournal of Organic ChemistryJournal Article2017
Revealing the Pharmacophore of Ipomoeassin F through Molecular EditingOrganic LettersJournal Article2016
Late-stage modification of C-3 tigoyl moiety of ipomoeassin F to enable SAR studies.Abstracts, 28th International Carbohydrate Symposium, New Orleans, LA, United States, July 17-21, 2016Abstract2016
Exploring the mode of action of ipomoeassin natural glycoresins.Abstracts, 28th International Carbohydrate Symposium, New Orleans, LA, United States, July 17-21, 2016Abstract2016
Understanding the functional mechanism of ipomoeassin natural glycoresins.Abstracts, 28th International Carbohydrate Symposium, New Orleans, LA, United States, July 17-21, 2016Abstract2016
Establishing a route for the synthesis of ipomoeassin F analogs containing a modified aglycone.Abstracts, 28th International Carbohydrate Symposium, New Orleans, LA, United States, July 17-21, 2016Abstract2016
Divergence of Antiangiogenic Activity and Hepatotoxicity of Different Stereoisomers of ItraconazoleClinical Cancer ResearchJournal Article2016
Total synthesis and biological evaluation of the C-11 epimer of ipomoeassin FAbstracts of Papers of the American Chemical SocietyAbstract2015
Total synthesis and SAR study of ipomoeassin FAbstracts of Papers of the American Chemical SocietyAbstract2015
Cytotoxic natural product Ipomoeassin F: SAR-guided probe design for target identificationAbstracts of Papers of the American Chemical SocietyAbstract2015
Chemical proteomics to the development of natural glycoconjugates towards novel anticancer agentsAbstracts of Papers of the American Chemical SocietyAbstract2015
Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cellsProceedings of the National Academy of Sciences of the United States of AmericaJournal Article2015
Total Synthesis and Biological Evaluation of Ipomoeassin F and Its Unnatural 11R-EpimerJournal of Organic ChemistryJournal Article2015