CHBC Faculty Publications

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Author: Sakon, Josh

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TitlePublication NamePub. TypeYear
Covalent Crosslinking of Colloidal Cellulose Nanocrystals for Multifunctional Nanostructured Hydrogels with Tunable Physicochemical PropertiesBiomacromoleculesJournal Article2022
Impact of species-based wood feedstock variability on physicochemical properties of cellulose nanocrystalsCelluloseJournal Article2022
Delivery of therapeutic agents by a collagen binding proteinUS11279922Patent2022
Delivery of therapeutic agents by a collagen binding proteinUS11001820Patent2021
Maximizing production of cellulose nanocrystals and nanofibers from pre-extracted loblolly pine kraft pulp: a response surface approachBioresources and BioprocessingJournal Article2020
Investigating the effects of hemicellulose pre-extraction on the production and characterization of loblolly pine nanocelluloseCelluloseJournal Article2020
Fusion proteins of collagen-binding domain and parathyroid hormoneUS10202434Patent2019
Delivery of therapeutic agents by a collagen binding proteinUS10213488Patent2019
Fusion proteins of collagen-binding domain and parathyroid hormoneUS10358471Patent2019
Cleavage resistant photoluminescent proteins and applications thereofUS10442842Patent2019
Fusion proteins of collagen-binding domain and parathyroid hormoneUS10519213Patent2019
Ca2+-induced orientation of tandem collagen binding domains from clostridial collagenase ColG permits two opposing functions of collagen fibril formation and retardationFEBS JournalJournal Article2018
Activation and binding mechanisms of the tandem collagen-binding domain of ColG collagenaseFASEB JournalAbstract2017
Multi-Domain Dynamic Studies of Calcium Bound Polycystic Kidney Disease-Like and Collagen Binding DomainsFASEB JournalAbstract2017
Using Small Angle X-ray Scattering to determine the role of Poly-cystic kidney disease-like domains in Clostridium histolyticumFASEB JournalAbstract2017
Delivery of therapeutic agents by a collagen binding proteinUS9579273Patent2017
Alternate carbohydrate and nontraditional inducer leads to increased productivity of a collagen binding domain fusion protein via fed-batch fermentationJournal of BiotechnologyJournal Article2016
Fluorescent ampicillin analogues as multifunctional disguising agents against opsonizationNanoscaleJournal Article2016
Delivery of therapeutic agents by a collagen binding proteinUS9526765Patent2016
Fusion proteins of collagen-binding domain and parathyroid hormoneUS9528099Patent2016
Structures of three polycystic kidney disease-like domains from Clostridium histolyticum collagenases ColG and ColHActa Crystallographica Section D-Structural BiologyJournal Article2015
Expression of a collagen-binding domain fusion protein: Effect of amino acid supplementation, inducer type, and culture conditionsBiotechnology ProgressJournal Article2015
Fusion proteins of collagen-binding domain and parathyroid hormoneUS9062300Patent2015
Parathyroid hormone linked to a collagen binding domain promotes hair growth in a mouse model of chemotherapy-induced alopecia in a dose-dependent mannerAnti-Cancer DrugsJournal Article2014
Treatment and prevention of chemotherapy-induced alopecia with PTH-CBD, a collagen-targeted parathyroid hormone analog, in a non-depilated mouse modelAnti-Cancer DrugsJournal Article2014
Treating osteoporosis by targeting parathyroid hormone to boneDrug Discovery TodayJournal Article2014
Pharmacokinetics in Rats of a Long-Acting Human Parathyroid Hormone-Collagen Binding Domain Peptide ConstructJournal of Pharmaceutical SciencesJournal Article2014
Structural Comparison of ColH and ColG Collagen-Binding Domains from Clostridium histolyticumJournal of BacteriologyJournal Article2013
Parathyroid Hormone Agonists Linked to a Collagen Binding Domain Increase Anagen Hair Follicles and Reduce Hair Loss in Mice with Alopecia AreataJournal of Bone and Mineral ResearchAbstract2013
Subcutaneous and Intravenous Single Dose Pharmacokinetics of PTH(1-34) and PTH-CBD, a Long-Acting Parathyroid Hormone Analog, in Sprague Dawley RatsJournal of Bone and Mineral ResearchAbstract2013
Therapy for Alopecia Areata in Mice Using Parathyroid Hormone Agonists and Antagonists, Linked to a Collagen-Binding DomainJournal of Investigative Dermatology Symposium ProceedingsJournal Article2013
Fusion proteins of collagen-binding domain and parathyroid hormoneUS8450273Patent2013
The Crystal Structure of the Polycystic Kidney Disease Domain (PKD) from Clostridium Histolyticum Collagenase: Insight into the Role of the PKD in CollagenaseBiophysical JournalAbstract2012
A Single Injection of the Anabolic Bone Agent, Parathyroid Hormone-Collagen Binding Domain (PTH-CBD), Results in Sustained Increases in Bone Mineral Density for up to 12 Months in Normal Female MiceCalcified Tissue InternationalJournal Article2012
Treatment for chemotherapy-induced alopecia in mice using parathyroid hormone agonists and antagonists linked to a collagen binding domainInternational Journal of CancerJournal Article2012
Treatment of alopecia in mice with a novel parathyroid hormone fusion proteinJournal of Investigative DermatologyAbstract2012
Treatment of Chemotherapy-Induced Alopecia in Mice with a Novel Parathyroid Hormone Fusion Protein: Prophylaxis Vs. TherapyJournal of Investigative MedicineAbstract2012
Probing the 3-D Structure, Dynamics, and Stability of Bacterial Collagenase Collagen Binding Domain (apo- versus holo-) by Limited Proteolysis MALDI-TOF MSJournal of the American Society for Mass SpectrometryJournal Article2012
Bacterial collagen-binding domain targets undertwisted regions of collagenProtein ScienceJournal Article2012
Collagen binding domains (CBD) fused to novel therapeutic proteins: Expression and isolation of CBD-parathyroid hormoneAbstracts of Papers, 241st ACS National Meeting and Exposition, Anaheim, CA, United States, March 27-31, 2011Abstract2011
Monthly Administration of a Novel PTH-Collagen Binding Domain Fusion Protein is Anabolic in MiceCalcified Tissue InternationalJournal Article2011
Prevention of chemotherapy-induced osteoporosis by cyclophosphamide with a long-acting form of parathyroid hormoneJournal of Endocrinological InvestigationJournal Article2011
Characterization of the Minimalistic Fgf-D2 Domain InterfaceBiophysical JournalAbstract2010
Aqueous-phase synthesis of monodisperse plasmonic gold nanocrystals using shortened single-walled carbon nanotubesChemical CommunicationsJournal Article2010
Treatment of Chemotherapy-Induced Osteoporosis and Alopecia with a Novel Fusion Protein in Young MiceJournal of Investigative MedicineJournal Article2010
A fusion protein of parathyroid hormone (PTH) and a collagen binding domain shows superior efficacy and longer duration of action compared to PTH(1-34) as an anabolic bone agent in normal female miceBoneJournal Article2009
Ca2+-induced linker transformation leads to a compact and rigid collagen-binding domain of Clostridium histolyticum collagenaseFEBS JournalJournal Article2009
Unidirectional Binding of Clostridial Collagenase to Triple Helical SubstratesJournal of Biological ChemistryJournal Article2009
Structural analysis of a novel hFGFR2D2 dimer: Insights into the FGF signaling pathwayAbstracts of Papers, 236th ACS National Meeting, Philadelphia, PA, United States, August 17-21, 2008Abstract2008
H-1, C-13 and N-15 resonance assignments of Ca2+ bound collagen-binding domain derived from a clostridial collagenaseBiomolecular NMR AssignmentsJournal Article2008
Hepatitis C virus NS3 helicase forms oligomeric structures that exhibit optimal DNA unwinding activity in vitroJournal of Biological ChemistryJournal Article2008
A Fusion Protein of Parathyroid Hormone (PTH) and a Collagen Binding Domain Shows Superior Efficacy and Longer Duration of Action Compared to PTH(1-34) as an Anabolic Bone Agent In Normal Female MiceJournal of Bone and Mineral ResearchJournal Article2008
Compounds and methods for inhibiting hepatitis C virus replicationUS7465537Patent2008
A new dimeric structure of FGFR D2 domain may contribute to the FGF signaling pathwayAbstracts of Papers, 234th ACS National Meeting, Boston, MA, United States, August 19-23, 2007Abstract2007
Collagen binding characteristics of collagen binding domain from clostridium histolyticum class I collaganaseJournal of Bone and Mineral ResearchJournal Article2007
Weekly administration of a novel parathyroid hormone - Collagen binding domain fusion protein increases bone mineral density by more than 15 percent in normal miceJournal of Bone and Mineral ResearchJournal Article2007
Cell wall-targeting domain of glycylglycine endopeptidase distinguishes among peptidoglycan cross-bridgesJournal of Biological ChemistryJournal Article2006
Structural and biological identification of residues on the surface of NS3 helicase required for optimal replication of the hepatitis C virusJournal of Biological ChemistryJournal Article2006
Catalytically enhanced endocellulase Cel5A from Acidothermus cellulolyticusApplied Biochemistry and BiotechnologyJournal Article2005
Identification and characterization of oligomeric structures formed by full-length nonstructural protein 3 from hepatitis C virusFASEB JournalConference Proceedings2005
C-terminal 26 amino acids of CPSRP54 are not required for targeting complex formation and LHCP integration in vitroAbstracts of Papers, 227th ACS National Meeting, Anaheim, CA, United States, March 27-April 1, 2004Abstract2004
Increased thermal tolerance of Thermobifida fusca beta-glucosidase by protein engineeringAbstracts of Papers, 227th ACS National Meeting, Anaheim, CA, United States, March 27-April 1, 2004Abstract2004
Proteins with simplified hydrophobic cores compared to other packing mutantsBiophysical ChemistryJournal Article2004
Regulation of the GTPase cycle in post-translational signal recognition particle-based protein targeting involves cpSRP43Journal of Biological ChemistryJournal Article2004
Crystal structure of dimeric HCVNS3 helicase in complex with DNA supports \"inch worm\"modelBiophysical JournalAbstract2003
A bacterial collagen-binding domain with novel calcium-binding motif controls domain orientationEMBO JournalJournal Article2003
Determination of the structure of staphylococcal nuclease mutants.Abstracts of Papers, 223rd ACS National Meeting, Orlando, FL, April 7-11, 2002Abstract2002
Improved cellulases through protein engineering.Abstracts of Papers, 223rd ACS National Meeting, Orlando, FL, April 7-11, 2002Abstract2002
Exploration of cellulose surface-binding properties of Acidothermus cellulolyticus Cel5A by site-specific mutagenesisApplied Biochemistry and BiotechnologyJournal Article2002
ATP stimulates signal recognition particle (SRP)/FtsY-supported protein integration in chloroplastsJournal of Biological ChemistryJournal Article2002
Structural analysis of core mutants and solvent-exposed mutants in the major alpha-helix of Staphylococcal nucleaseBiophysical JournalAbstract2001
Characterization of metal affinity of green fluorescent protein and its purification through salt promoted, immobilized metal affinity chromatographyJournal of Chromatography AJournal Article2001
Contribution of hydrogen bonding to the structure and stability of staphylococcal nuclease.Abstracts of Papers, 219th ACS National Meeting, San Francisco, CA, March 26-30, 2000Abstract2000
Increasing the thermostability or staphylococcal nuclease: Implications for the origin of protein thermostability.Biophysical JournalAbstract2000
Increasing the thermostability of staphylococcal nuclease: Implications for the origin of protein thermostabilityJournal of Molecular BiologyJournal Article2000
Ab initio study of the conformational dependence of the nonplanarity of the peptide groupJournal of Physical Chemistry AJournal Article2000
Catalytically enhanced cellulase.Abstracts of Papers, 217th ACS National Meeting, Anaheim, CA, March 21-25, 1999Abstract1999
Cellulase action as viewed using an analytical membrane-reactor assay.Abstracts of Papers, 217th ACS National Meeting, Anaheim, CA, March 21-25, 1999Abstract1999
Designing catalytically enhanced endocellulase.Abstracts of Papers, 217th ACS National Meeting, Anaheim, CA, March 21-25, 1999Abstract1999
Structure and mechanism of endo/exocellulase E4 from Thermomonospora fuscaBiophysical JournalAbstract1998
Roles of the catalytic domain and two cellulose binding domains of Thermomonospora fusca E4 in cellulose hydrolysisJournal of BacteriologyJournal Article1998
Structure and mechanism of endo/exocellulase E4 from Thermomonospora fuscaNature Structural BiologyJournal Article1997