CHBC Faculty Publications

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Author: Koeppe II, Roger Erdman

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TitlePublication NamePub. TypeYear
Illuminating Disorder Induced by Glu in a Stable Arg-Anchored Transmembrane HelixACS OmegaJournal Article2021
Lipid-Dependent Titration of Glutamic Acid at a Bilayer Membrane InterfaceACS OmegaJournal Article2021
Examination of pH dependency and orientation differences of membrane spanning alpha helices carrying a single or pair of buried histidine residuesBiochimica et Biophysica Acta-BiomembranesJournal Article2021
Membrane electrostatics sensed by tryptophan anchors in hydrophobic model peptides depends on non-aromatic interfacial amino acids: implications in hydrophobic mismatchFaraday DiscussionsJournal Article2021
Influence of interfacial tryptophan residues on an arginine-flanked transmembrane helixBiochimica et Biophysica Acta-BiomembranesJournal Article2020
Comparing Interfacial Trp, Interfacial His and pH Dependence for the Anchoring of Tilted Transmembrane Helical PeptidesBiomoleculesJournal Article2020
Attempted "Rescue'' of Glutamic Acid by Arginine in a Transmembrane HelixBiophysical JournalJournal Article2020
Effect of Charged Lipids on the Ionization Behavior of Glutamic Acid-Containing Transmembrane HelicesBiophysical JournalJournal Article2020
Effect of pH and Lipid Composition on Membrane-Spanning Helices with Glutamic Acid Examined by Solid-State NmrBiophysical JournalJournal Article2020
Lipid-Dependent Titration of Glutamic Acid at a Membrane InterfaceBiophysical JournalJournal Article2020
Flanking aromatic residue competition influences transmembrane peptide helix dynamicsFEBS LettersJournal Article2020
Transmembrane Helix Integrity versus Fraying To Expose Hydrogen Bonds at a Membrane-Water InterfaceBiochemistryJournal Article2019
Helix Fraying and Orientation of a Transmembrane Peptide having a Long Hydrophobic Core and Anchored by Interfacial Arginine ResiduesBiophysical JournalJournal Article2019
Influence of Charged Lipids on Glutamic Acid Containing Transmembrane HelicesBiophysical JournalJournal Article2019
Characterization of Alpha-Helix Distortions at a Membrane Surface and a Partial 3(10)-Helix by Solid-State NMRBiophysical JournalJournal Article2019
Lipid Optimization to Improve the Solid-State NMR Spectra from Membrane-Spanning Helices with Glutamic AcidBiophysical JournalJournal Article2019
Novel F13,F15 Gramicidin Subunits Predicted to Cross Bilayer Membranes and form Ion ChannelsBiophysical JournalJournal Article2019
Position Dependent Orientation Difference of Transmembrane Peptides Flanked by Single or Multiple Histidine ResiduesBiophysical JournalJournal Article2019
Influence of Lipid Saturation, Hydrophobic Length and Cholesterol on Double-Arginine-Containing Helical Peptides in Bilayer MembranesChemBioChemJournal Article2019
Antidepressants are modifiers of lipid bilayer propertiesJournal of General PhysiologyJournal Article2019
Breaking the Backbone: Central Arginine Residues Induce Membrane Exit and Helix Distortions within a Dynamic Membrane PeptideJournal of Physical Chemistry BJournal Article2019
Impact of the INBRE summer student mentored research program on undergraduate students in ArkansasAdvances in Physiology EducationJournal Article2018
Helix formation and stability in membranesBiochimica et Biophysica Acta-BiomembranesJournal Article2018
Membrane Bending Moduli of Coexisting Liquid Phases Containing Transmembrane PeptideBiophysical JournalJournal Article2018
Detection of Helix Fraying of a Transmembrane Peptide with Two Interfacial Arginine ResiduesBiophysical JournalJournal Article2018
Dissecting Drug Physico-Chemical Profiles as They Relate to their Bilayer Modifying PotencyBiophysical JournalJournal Article2018
Control of Transmembrane Helix Dynamics by Interfacial Tryptophan ResiduesBiophysical JournalJournal Article2018
Analyzing the Effects of Placing Central Arginine Residues within a Highly Dynamic Transmembrane Alpha-HelixBiophysical JournalJournal Article2018
Influence of Saturation and Hydrophobic Length of Lipid Bilayers on Twin-Arginine Containing Helical PeptidesBiophysical JournalJournal Article2018
Ionization and Dynamic Properties of Single and Multiple Histidine Residues on a Transmembrane Helical BackboneBiophysical JournalJournal Article2018
Gramicidin Subunits that Cross Membranes and form Ion ChannelsBiophysical JournalJournal Article2018
Wavelength-Selective Fluorescence of a Model Transmembrane Peptide: Constrained Dynamics of Interfacial Tryptophan AnchorsJournal of FluorescenceJournal Article2018
Influence of glutamic acid residues and pH on the properties of transmembrane helicesBiochimica et Biophysica Acta-BiomembranesJournal Article2017
Interfacial Tryptophan Residues Govern Transmembrane Helix DynamicsBiophysical JournalJournal Article2017
Exchange of Gramicidin between Lipid Bilayers: Implications for the Mechanism of Channel FormationBiophysical JournalJournal Article2017
Response of GWALP23 Transmembrane Peptides to Incorporation of Specific Pairs of Buried Charged Arginine ResiduesBiophysical JournalJournal Article2017
Solid-State NMR Investigations of Transmembrane Helix InteractionsBiophysical JournalJournal Article2017
Detection of Helix Fraying in Transmembrane Helices with Interfacial Histidine ResiduesBiophysical JournalJournal Article2017
Influence of Paired Histidine Residues on Transmembrane Helix Orientation and DynamicsBiophysical JournalJournal Article2017
The ionization properties of histidine in lipid bilayersEuropean Biophysics Journal with Biophysics LettersJournal Article2017
Characterizing Residue-Bilayer Interactions Using Gramicidin A as a Scaffold and Tryptophan Substitutions as ProbesJournal of Chemical Theory and ComputationJournal Article2017
Influence of High pH and Cholesterol on Single Arginine-Containing Transmembrane Peptide HelicesBiochemistryJournal Article2016
Investigating Possible Interactions between Ionizable Residues in Model Transmembrane PeptidesBiophysical JournalJournal Article2016
Cholesterol Influence on Arginine-Containing Transmembrane PeptidesBiophysical JournalJournal Article2016
A General Mechanism for Drug Promiscuity: Studies with Amiodarone and Other AntiarrhythmicsBiophysical JournalJournal Article2016
Varied Approaches to the Ionization Behavior of Specific Glu Residues that Face the Lipids in Transmembrane HelicesBiophysical JournalJournal Article2016
Helix Fraying May Stabilize Transmembrane Alpha HelicesBiophysical JournalJournal Article2016
Monitoring the Consequences of Relocating the Tryptophan Anchors on Transmembrane Peptide Dynamics and AlignmentBiophysical JournalJournal Article2016
Use of Transmembrane Peptides to Understand Ionization Properties of Histidine Residues in Lipid BilayersBiophysical JournalJournal Article2016
Solid-State NMR Investigations of a Transmembrane Peptide having Interfacial Histidine ResiduesBiophysical JournalJournal Article2016
Juxta-terminal Helix Unwinding as a Stabilizing Factor to Modulate the Dynamics of Transmembrane HelicesChemBioChemJournal Article2016
Cover Picture: Juxta-terminal Helix Unwinding as a Stabilizing Factor to Modulate the Dynamics of Transmembrane Helices (ChemBioChem 6/2016)ChemBioChemJournal Article2016
Ionization Properties of Histidine Residues in the Lipid Bilayer Membrane EnvironmentJournal of Biological ChemistryJournal Article2016
Lipid bilayer thickness determines cholesterol's location in model membranesSoft MatterJournal Article2016
Dynamic regulation of lipid-protein interactionsBiochimica et Biophysica Acta-BiomembranesJournal Article2015
Comparing Peptide-Lipid Interactions and Antimicrobial Activities of Peptides with Similar "Core'' Lengths But Variable Arginine and Tryptophan ResiduesBiophysical JournalJournal Article2015
Influence of Cholesterol on Single Arginine-Containing Transmembrane Helical PeptidesBiophysical JournalJournal Article2015
Ionization-Dependent Behavior of Transmembrane Helices that Incorporate Glu or Tyr ResiduesBiophysical JournalJournal Article2015
Detection of Helix Fraying in Designed Transmembrane Alpha HelicesBiophysical JournalJournal Article2015
Response of GWALP Transmembrane Peptides to Incorporation of Buried Histidine ResiduesBiophysical JournalJournal Article2015
Influence of a Potentially Destabilizing Central Tryptophan on Transmembrane Helix DomainsBiophysical JournalJournal Article2015
Disorderly Polyunsaturated Fatty Acids and Orderly Cholesterol: Just How do they get along in a Membrane?Biophysical JournalJournal Article2015
A general mechanism for drug promiscuity: Studies with amiodarone and other antiarrhythmicsJournal of General PhysiologyJournal Article2015
Comparisons of Interfacial Phe, Tyr, and Trp Residues as Determinants of Orientation and Dynamics for GWALP Transmembrane PeptidesBiochemistryJournal Article2014
Importance of indole N-H hydrogen bonding in the organization and dynamics of gramicidin channelsBiochimica et Biophysica Acta-BiomembranesJournal Article2014
Characterizing Moderately Short Antimicrobial Tryptophan/Arginine-Rich PeptidesBiophysical JournalJournal Article2014
Ion-Induced Defect Permeation of Lipid MembranesBiophysical JournalJournal Article2014
Influence of Glutamic Acid Residues on the Properties of Model Membrane-Spanning HelicesBiophysical JournalJournal Article2014
Influence of pH and Histidine Residues on Membrane-Spanning Helical PeptidesBiophysical JournalJournal Article2014
Influence of a Central Tryptophan and of Cholesterol on the Properties of Defined Transmembrane Helical PeptidesBiophysical JournalJournal Article2014
All-Atom Simulation and Continuum Elastic Theory of Gramicidin a in Binary Component Lipid BilayersBiophysical JournalJournal Article2014
Comparison of Interfacial Tyrosine, Tryptophan and Phenylalanine Residues as Determinants of Orientation and Dynamics of Transmembrane PeptidesBiophysical JournalJournal Article2013
Statins Alter Lipid Bilayer PropertiesBiophysical JournalJournal Article2013
Influence of pH and Side-Chain Negative Charge on the Behavior of Designed Transmembrane Peptides in Lipid BilayersBiophysical JournalJournal Article2013
Influence of Histidine Residues on Transmembrane Helix AlignmentBiophysical JournalJournal Article2013
Interactions of drugs and amphiphiles with membranes: modulation of lipid bilayer elastic properties by changes in acyl chain unsaturation and protonationFaraday DiscussionsJournal Article2013
Phosphoinositides alter lipid bilayer propertiesJournal of General PhysiologyJournal Article2013
Single Tryptophan and Tyrosine Comparisons in the N-Terminal and C-Terminal Interface Regions of Transmembrane GWALP PeptidesJournal of Physical Chemistry BJournal Article2013
Buried lysine, but not arginine, titrates and alters transmembrane helix tiltProceedings of the National Academy of Sciences of the United States of AmericaJournal Article2013
Properties of Membrane-Incorporated WALP Peptides That Are Anchored on Only One EndBiochemistryJournal Article2012
Proline Kink Angle Distributions for GWALP23 in Lipid Bilayers of Different ThicknessesBiochemistryJournal Article2012
Tyrosine Replacing Tryptophan as an Anchor in GWALP PeptidesBiochemistryJournal Article2012
Origins of Non-Selective Ion Transport across Lipid BilayersBiophysical JournalJournal Article2012
Statins Modify Lipid Bilayer PropertiesBiophysical JournalJournal Article2012
Response of GWALP Transmembrane Peptides to Titration of a Buried LysineBiophysical JournalJournal Article2012
Importance of Aromatic Anchor Residue Identity and Location for the Tilt and Dynamics of Transmembrane PeptidesBiophysical JournalJournal Article2012
Characterization of Antimicrobial Peptides Relating to Shortened RWALP Model PeptidesBiophysical JournalJournal Article2012
Accommodation of a Central Arginine in a Transmembrane Peptide by Changing the Placement of Anchor ResiduesJournal of Physical Chemistry BJournal Article2012
Membrane Organization and Dynamics of "Inner Pair" and "Outer Pair" Tryptophan Residues in Gramicidin ChannelsJournal of Physical Chemistry BJournal Article2012
Regulating membrane function by altering lipid bilayer elastic propertiesAbstracts of Papers of the American Chemical SocietyJournal Article2011
Response of GWALP Transmembrane Peptides to Changes in the Tryptophan Anchor PositionsBiochemistryJournal Article2011
The Membrane Interface Dictates Different Anchor Roles for "Inner Pair" and "Outer Pair" Tryptophan Indole Rings in Gramicidin A ChannelsBiochemistryJournal Article2011
On the Treatment of Dynamics During Combined H-2 GALA and N-15/H-1 PISEMA Analysis of Transmembrane Peptide Tilt using Solid-State NMR DataBiophysical JournalJournal Article2011
On the Combined Analysis of H-2 and N-15/H-1 Solid-State NMR Data for Determination of Transmembrane Peptide Orientation and DynamicsBiophysical JournalJournal Article2011
Fenamates Alter Bilayer PropertiesBiophysical JournalJournal Article2011
Exchange of Gramicidin between Lipid Bilayers: Implications for the Mechanism of Channel Formation and GatingBiophysical JournalJournal Article2011
A Proline Kink in GWALP23Biophysical JournalJournal Article2011
Antidepressants Modify Lipid Bilayer PropertiesBiophysical JournalJournal Article2011
Using Tyrosine to Anchor a Transmembrane PeptideBiophysical JournalJournal Article2011
Influence of Glycine Substitutions on Designed Proline-Containing Transmembrane PeptidesBiophysical JournalJournal Article2011
Comparison of Proline Substitutions at Positions 8 and 10 in WALP19Biophysical JournalJournal Article2011
Statins Modify Bilayer Mechanical PropertiesBiophysical JournalJournal Article2011
Effects of green tea catechins on gramicidin channel function and inferred changes in bilayer propertiesFEBS LettersJournal Article2011
Gramicidin A Backbone and Side Chain Dynamics Evaluated by Molecular Dynamics Simulations and Nuclear Magnetic Resonance Experiments. I: Molecular Dynamics SimulationsJournal of Physical Chemistry BJournal Article2011
Gramicidin A Backbone and Side Chain Dynamics Evaluated by Molecular Dynamics Simulations and Nuclear Magnetic Resonance Experiments. II: Nuclear Magnetic Resonance ExperimentsJournal of Physical Chemistry BJournal Article2011
Polar Groups in Membrane Channels: Consequences of Replacing Alanines with Serines in Membrane-Spanning Gramicidin ChannelsBiochemistryJournal Article2010
Charged and Aromatic Anchoring Amino Acids Affect the Orientation of Transmembrane Peptides: A Deuterium NMR StudyBiophysical JournalJournal Article2010
Thiazolidinediones Alter Lipid Bilayer Properties and Native Voltage-Gated Sodium Channel FunctionBiophysical JournalJournal Article2010
Antidepressants Modify Lipid Bilayer PropertiesBiophysical JournalJournal Article2010
Sensitivity of Coarse Grain Models of Peptides to the Introduction of Charged Residues in Model Peptides and Bacterial ChemoreceptorsBiophysical JournalJournal Article2010
Observation of Backbone C-alpha-Deuteron Signals in Solid-State NMR Spectra of Labeled Alanines in Oriented Transmembrane PeptidesBiophysical JournalJournal Article2010
Influence of WALP Peptides on Phase Behavior of Cholesterol Containing Ternary Lipid MixturesBiophysical JournalJournal Article2010
Helical distortion in tryptophan- and lysine-anchored membrane-spanning alpha-helices as a function of hydrophobic mismatch: a solid-state deuterium NMR investigation using the geometric analysis of labeled alanines method. (vol 94, pg 480, 2008)Biophysical JournalJournal Article2010
NSAIDs Alter Bilayer Properties by a Common MechanismBiophysical JournalJournal Article2010
Charged or Aromatic Anchor Residue Dependence of Transmembrane Peptide TiltJournal of Biological ChemistryJournal Article2010
A Combined Experimental and Theoretical Study of Ion Solvation in Liquid N-MethylacetamideJournal of the American Chemical SocietyJournal Article2010
Changes in Transmembrane Helix Alignment by Arginine Residues Revealed by Solid-State NMR Experiments and Coarse-Grained MD SimulationsJournal of the American Chemical SocietyJournal Article2010
Amphiphile regulation of ion channel function by changes in the bilayer spring constant.Proceedings of the National Academy of Sciences of the United States of AmericaJournal Article2010
Influence of Proline upon the Folding and Geometry of the WALP19 Transmembrane PeptideBiochemistryJournal Article2009
Development of a Drude Polarizable Force Field for Ion-water and Ion-NMA Interactions and Application to Selectivity in Ion ChannelsBiophysical JournalJournal Article2009
Use of Transmembrane Peptides to Investigate Arginine Interactions with Lipid BilayersBiophysical JournalJournal Article2009
Orientation of Single-Span Transmembrane Peptides Investigated by Independent Solid-State NMR Methods: GALA and PISEMABiophysical JournalJournal Article2009
Influence of Proline upon the Folding and Geometry of the WALP19 Transmembrane PeptideBiophysical JournalJournal Article2009
The Insulin-sensitizers Troglitazone And Rosiglitazone Alter Lipid Bilayer PropertiesBiophysical JournalJournal Article2009
Conformation of the Transmembrane Domain of the Anthrax Toxin ReceptorBiophysical JournalJournal Article2009
Evaluating Gramicidin A Channel Backbone Dynamics by Molecular Dynamics and Nuclear Magnetic ResonanceBiophysical JournalJournal Article2009
Comparison of Mechanical and Magnetic Alignment of WALP-like Peptides for Solid-State NMRBiophysical JournalJournal Article2009
Half-Anchored WALP Peptides: Effect Of Anchor Position On Peptide OrientationBiophysical JournalJournal Article2009
NSAIDs Alter Lipid Bilayer Mechanical PropertiesBiophysical JournalJournal Article2009
Solid-State NMR Approaches to Transmembrane Peptide TiltAbstracts of Papers of the American Chemical SocietyJournal Article2008
Experimental Solvation of KCl and NaCl in N-MethylacetamideAbstracts of Papers of the American Chemical SocietyJournal Article2008
Is there a preferential interaction between cholesterol and tryptophan residues in membrane proteins?BiochemistryJournal Article2008
Helical distortion in tryptophan- and lysine-anchored membrane-spanning alpha-helices as a function of hydrophobic mismatch: A solid-state deuterium NMR investigation using the geometric analysis of labeled alanines methodBiophysical JournalJournal Article2008
Role of tryptophan residues in gramicidin channel organization and functionBiophysical JournalJournal Article2008
The preference of tryptophan for membrane interfaces - Insights from n-methylation of tryptophans in gramicidin channelsJournal of Biological ChemistryJournal Article2008
Comparison of "Polarization Inversion with Spin Exchange at Magic Angle" and "Geometric Analysis of Labeled Alanines" methods for transmembrane helix alignmentJournal of the American Chemical SocietyJournal Article2008
NMR Experiments for the measurement of carbon relaxation properties in l3C, I5N-labeled gramicidin channelsAbstracts of Papers of the American Chemical SocietyJournal Article2007
Bilayer thickness and membrane protein function: An energetic perspectiveAnnual Review of Biophysics and Biomolecular StructureJournal Article2007
Curcumin is a modulator of bilayer material propertiesBiochemistryJournal Article2007
Orientation and motion of tryptophan interfacial anchors in membrane-spanning peptidesBiochemistryJournal Article2007
Lipid interactions of the transmembrane domain of anthrax toxin receptorBiophysical JournalJournal Article2007
(-)-epigallocatechin-3-gallate (EGCG) is a potent modifier of gramicidin functionBiophysical JournalJournal Article2007
Is there a special interaction between cholesterol and tryptophan?Biophysical JournalJournal Article2007
Backbone and side-chain dynamics of gramicidin channels by N-15- and C-13-NMR relaxationBiophysical JournalJournal Article2007
Intrinsic kinking of transmembrane alpha-helical peptides as a function of hydrophobic mismatchBiophysical JournalJournal Article2007
Orientations of anchored membrane-spanning peptides deduced from 2H NMR spectra using the GALA MethodBiophysical JournalJournal Article2007
Concerning tryptophan and protein-bilayer interactionsJournal of General PhysiologyJournal Article2007
Multivariate data analysis for enhanced interpretation of electrochemical impedance spectra of gramicidin-ion interactions in phospholipid monolayersLangmuirJournal Article2007
Single-molecular methods for monitoring changes in bilayer elastic properties.Methods in Membrane LipidsBook Section2007
Docosahexaenoic acid alters bilayer elastic propertiesProceedings of the National Academy of Sciences of the United States of AmericaJournal Article2007
2H exchange into the indole ring in gramicidin peptidesAbstracts of Papers of the American Chemical SocietyJournal Article2006
Transmembrane peptides stabilize inverted cubic phases in a biphasic length-dependent manner: Implications for protein-induced membrane fusionBiophysical JournalJournal Article2006
Effect of linker length on avidin binding to biotinylated gramicidin AInternational Journal of Peptide Research and TherapeuticsJournal Article2006
Manipulating lipid bilayer material properties using biologically active amphipathic moleculesJournal of Physics-Condensed MatterJournal Article2006
Microphysics of ion movement through Gramicidin channelsAbstracts of Papers of the American Chemical SocietyJournal Article2005
In situ deuteration of Trp indole rings in peptidesBiophysical JournalJournal Article2005
Modulation of mechanosensitive ion channels by the peptide GsMTx4: Evidence for a lipid bilayer dependent mechanismBiophysical JournalJournal Article2005
Influence of Lys or Arg on the intrinsic tilt of membrane-spanning WALP peptidesBiophysical JournalJournal Article2005
Modification of gramicidin channel function by PUFAs depends on double-bond structureBiophysical JournalJournal Article2005
Gadolinium modulation of gramicidin a channel functionBiophysical JournalJournal Article2005
Gramicidin channelsIEEE Transactions on NanobioscienceJournal Article2005
Importance of tensor asymmetry for the analysis of H-2 NMR spectra from deuterated aromatic ringsJournal of the American Chemical SocietyJournal Article2005
Capsaicin regulates voltage-dependent sodium channels by altering lipid bilayer elasticityMolecular PharmacologyJournal Article2005
Dynamics of lipid-embedded alpha-helices using solid state deuterium NMR and spectral simulationBiophysical JournalJournal Article2004
Tilt angles of transmembrane model peptides in oriented and non-oriented lipid bilayers as determined by H-2 solid-state NMRBiophysical JournalJournal Article2004
Selective deuteration of the Trp indole ring and indole analogues for NMR spectroscopyBiophysical JournalJournal Article2004
Modification of gramicidin channel function by poly-unsaturated fatty acidsBiophysical JournalJournal Article2004
Modification of gramicidin channel function by polyunsaturated fatty acidsJournal of General PhysiologyJournal Article2004
Designing a membrane-spanning force transducerJournal of General PhysiologyJournal Article2004
Nonchiral effects of a peptide inhibitor of mechanosensitive channels: Evidence for a bilayer-dependent mechanismJournal of General PhysiologyJournal Article2004
Regulation of sodium channel function by bilayer elasticity: the importance of hydrophobic coupling. Effects of micelle-forming amphiphiles and cholesterolJournal of General PhysiologyJournal Article2004
Interaction of gramicidin derivatives with phospholipid monolayersLangmuirJournal Article2004
Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomersNatureJournal Article2004
Are biosensor arrays in one membrane possible? A combination of multifrequency impedance measurements and chemometricsAnalytical and Bioanalytical ChemistryJournal Article2003
Genistein can modulate channel function by a phosphorylation-independent mechanism: Importance of hydrophobic mismatch and bilayer mechanicsBiochemistryJournal Article2003
Interfacial anchor properties of tryptophan residues in transmembrane peptides can dominate over hydrophobic matching effects in peptide-lipid interactionsBiochemistryJournal Article2003
Hydrophobic mismatch between helices and lipid bilayersBiophysical JournalJournal Article2003
Gramicidin channels with Tryptophan (Trp) substituted by 7-aza-Trp or 1-Methyl-7-aza-TrpBiophysical JournalJournal Article2003
Do membrane mediated effects explain the anticonvulsant activity of valproate?Biophysical JournalJournal Article2003
Modification of gramicidin channel function by poly-unsaturated fatty acidsBiophysical JournalJournal Article2003
Hydrophobic coupling of lipid bilayer energetics to channel functionJournal of General PhysiologyJournal Article2003
Combined experimental/theoretical refinement of indole ring geometry using deuterium magnetic resonance and ab initio calculationsJournal of the American Chemical SocietyJournal Article2003
Dynamics of membrane-spanning peptides investigated by solid state deuterium NMR and spectral simulation.Abstracts of Papers of the American Chemical SocietyJournal Article2002
The subunit interface for right-handed gramicidin channels that begin with D- or L-amino acidsBiophysical JournalJournal Article2002
Use of H-2-NMR to examine a tryptophan-anchored membrane-spanning peptideBiophysical JournalJournal Article2002
Geometry and intrinsic tilt of a tryptophan-anchored transmembrane alpha-helix determined by H-2 NMRBiophysical JournalJournal Article2002
Properties of gramicidin A channels with modified tryptophan indole ringsBiophysical JournalJournal Article2002
Peptide backbone modifications in gramicidin channelsBiophysical JournalJournal Article2002
Probing lipid-protein interactions in biological membranesBiophysical JournalJournal Article2002
Double-barreled gramicidin channelsBiophysical JournalJournal Article2002
Mechanical properties of biological membranesJournal of General PhysiologyJournal Article2002
Hydrophobic matching mechanism investigated by molecular dynamics simulationsLangmuirJournal Article2002
Sensitivity of single membrane-spanning alpha-helical peptides to hydrophobic mismatch with a lipid bilayer: Effects on backbone structure, orientation, and extent of membrane incorporationBiochemistryJournal Article2001
Peptide backbone chemistry and membrane channel function: Effects of a single amide-to-ester replacement on gramicidin channel structure and functionBiochemistryJournal Article2001
Deuterium NMR study of the importance of the lipid ester carbonyl for the interfacial membrane anchoring by tryptophan residuesBiophysical JournalJournal Article2001
Disrupting tryptophan's ability to form hydrogen bonds increases the conformational accessibility of gramicidin channelsBiophysical JournalJournal Article2001
The snorkeling behavior of side chains in model transmembrane peptides is dependent on the lipid headgroup compositionBiophysical JournalJournal Article2001
Deuterium NMR investigations of gated homodimeric gramicidin channelsBiophysical JournalJournal Article2001
Designing gramicidins for use as force transducers to measure bilayer deformation energiesBiophysical JournalJournal Article2001
Identification of the kinetic model for a voltage-dependent gramicidin channelBiophysical JournalJournal Article2001
Gramidicin channels as molecular force transducers in biological membranesBiophysical JournalJournal Article2001
Sequence determinants for the folding of gramicidin channelsBiophysical JournalJournal Article2001
Hydrophobic matching and membrane organizationBiophysical JournalJournal Article2001
Lipid modulation of the properties of channel-forming peptidesBiophysical JournalJournal Article2001
2H solid-state NMR structural and dynamic studies of biotinylated gramicidinsBiophysical JournalJournal Article2001
Interfacial positioning and stability of transmembrane peptides in lipid bilayers studied by combining hydrogen/deuterium exchange and mass spectrometryJournal of Biological ChemistryJournal Article2001
Tryptophan-anchored transmembrane peptides promote formation of nonlamellar phases in phosphatidylethanolamine model membranes in a mismatch-dependent mannerBiochemistryJournal Article2000
Neighboring aliphatic/aromatic side chain interactions between residues 9 and 10 in gramicidin channelsBiochemistryJournal Article2000
Studies of tryptophans in membrane-spanning "WALP" peptides by deuterium NMR spectroscopyBiophysical JournalJournal Article2000
Membrane-spanning alpha-helical peptides stabilize Q(mu) phases in a peptide length-dependent fashionBiophysical JournalJournal Article2000
Ability of aromatic residues to form hydrogen bonds is important for the organization of membrane spanning structuresBiophysical JournalJournal Article2000
Backbone modifications in gramicidin channelsBiophysical JournalJournal Article2000
Desformylgramicidin: A model channel with an extremely high water permeabilityBiophysical JournalJournal Article2000
Interaction of WALP peptides with lipid bilayers: Molecular dynamics simulationsBiophysical JournalJournal Article2000
The effect of peptide/lipid hydrophobic mismatch on the phase behavior of model membranes mimicking the lipid composition in Escherichia coli membranesBiophysical JournalJournal Article2000
Membrane stiffness regulates the inactivation of rat muscle sodium channelsBiophysical JournalJournal Article2000
Synthesis of C-linked gramicidin channel subunitsBiophysical JournalJournal Article2000
Electrospray ionization mass spectrometry as a novel tool to analyze hydrogen/deuterium exchange kinetics of transmembrane peptides in lipid bilayersBiophysical JournalJournal Article2000
Detection and properties of single- and double-stranded gramicidin channelsBiophysical JournalJournal Article2000
Kinetic studies on ion movement through a channel of known structureJournal of General PhysiologyJournal Article2000
Folding determinants for gramicidin channels in membranesJournal of General PhysiologyJournal Article2000
Voltage-dependent gating of a homodimeric gramicidin channel with a chiral mismatchJournal of General PhysiologyJournal Article2000
Mechanical properties of biological membranes: Gramicidin channels as molecular force transducersJournal of General PhysiologyJournal Article2000
Chemical modifications in the gramicidin channel backboneJournal of General PhysiologyJournal Article2000
Hydrogen bonding ability of aromatic residues is important for the organization of membrane-spanning structuresJournal of General PhysiologyJournal Article2000
Electrospray ionization mass spectrometry as a tool to analyze hydrogen/deuterium exchange kinetics of transmembrane peptides in lipid bilayersProceedings of the National Academy of Sciences of the United States of AmericaJournal Article2000
Modulation of gramicidin channel structure and function by the aliphatic "spacer" residues 10, 12, and 14 between the tryptophansBiochemistryJournal Article1999
Application of x-ray off-plane scattering to gramicidin analogues in lipid bilayersBiophysical JournalJournal Article1999
Free energy simulations - thermodynamic reversibility and statistical significanceBiophysical JournalJournal Article1999
Influence of hydrophobic alpha-helical peptides on the phase behavior of model membranes able to form an isotropic phaseBiophysical JournalJournal Article1999
Steric interactions of valines 1, 5, and 7 in [valine 5, D-Alanine 8] gramicidin A channelsBiophysical JournalJournal Article1999
Different anchoring behavior of tryptophan and lysine in model transmembrane protein segmentsBiophysical JournalJournal Article1999
Different membrane anchoring positions of tryptophan and lysine in synthetic transmembrane alpha-helical peptidesJournal of Biological ChemistryJournal Article1999
Gramicidin channel controversy - the structure in a lipid environmentNature Structural BiologyJournal Article1999
Gramicidin channel controversy - revisitedNature Structural BiologyJournal Article1999
Influence of lipid/peptide hydrophobic mismatch on the thickness of diacylphosphatidylcholine bilayers. A H-2 NMR and ESR study using designed transmembrane alpha-helical peptides and gramicidin ABiochemistryJournal Article1998
Effects of hydrophobic mismatch on the interaction between transmembrane alpha-helical peptides with TRP anchors, and lipid bilayers of phosphatidylcholine and phosphatidnethanolamineBiophysical JournalJournal Article1998
Conformational preference of [VAL(5)]gLW and [VAL(5)ALA(8)]gLW channels in phospholipid bilayersBiophysical JournalJournal Article1998
Polylysine decelerates channel kinetics of negatively charged gramicidin as shown by sensitized photoinactivationBiophysical JournalJournal Article1998
Influence of an amide-to-ester replacement in the gramicidin channel backbone on ion permeability and channel stabilityBiophysical JournalJournal Article1998
Importance of tryptophan dipoles for protein function: 5-fluorination of tryptophans in gramicidin A channelsJournal of the American Chemical SocietyJournal Article1998
Modulation of membrane structure and function by hydrophobic mismatch between proteins and lipidsPure and Applied ChemistryJournal Article1998
The role of hydrophobic mismatch and interfacially localized tryptophans in peptide-lipid interactionsBiophysical JournalJournal Article1997
Thermodynamic reversibility and statistical convergence of alchemical free energy simulationsBiophysical JournalJournal Article1997
Influence of membrane-spanning alpha-helical peptides on the phase behavior of the dioleoylphosphatidylcholine/water systemBiophysical JournalJournal Article1997
Double-stranded channels are formed by gramicidin analog, V(9)GLWBiophysical JournalJournal Article1997
Neighboring aliphatic aromatic side chain interactions between residues 9 and 10 in gramicidin channelsBiophysical JournalJournal Article1997
Gramicidin channels in phospholipid bilayers with unsaturated acyl chainsBiophysical JournalJournal Article1997
Changes in bilayer thickness induced by gramicidin and alpha-helical peptides in model membranes of diacyl-phosphatidylcholineBiophysical JournalJournal Article1997
A study of channel kinetics of gramicidin analogues in planar bilayer membranes by sensitized photoinactivationBiophysical JournalJournal Article1997
Engineering the gramicidin channelAnnual Review of Biophysics and Biomolecular StructureJournal Article1996
Conformation of the acylation site of palmitoylgramicidin in lipid bilayers of dimyristoylphosphatidylcholineBiochemistryJournal Article1996
Induction of nonbilayer structures in diacylphosphatidylcholine model membranes by transmembrane alpha-helical peptides: Importance of hydrophobic mismatch and proposed role of tryptophansBiochemistryJournal Article1996
Determination of the relative stability of different conformers of gramicidin a analogues - A novel free energy perturbation approachBiophysical JournalJournal Article1996
Conformational studies of mixtures of gramicidin A analogues that differ in length by +/-1 residueBiophysical JournalJournal Article1996
Residue 5 of gramicidin LW as a conformational ''switch''Biophysical JournalJournal Article1996
Induction of non-bilayer structures by alpha-helical peptides in a model membranes of diacylphosphatidylcholine and diacylphosphatidylethanolamineBiophysical JournalJournal Article1996
Influence of spacer residues between tryptophans on gramicidin channel propertiesBiophysical JournalJournal Article1996
Gramicidin channels in phospholipid bilayers having unsaturated acyl chainsBiophysical JournalJournal Article1996
Gramicidin channels - A solvable membrane ''protein'' folding problemIndian Journal of Biochemistry and BiophysicsJournal Article1996
Folding of gramicidin channels.Progress in Biophysics and Molecular BiologyJournal Article1996
Effects on lipid organization of transmembrane model peptidesProgress in Biophysics and Molecular BiologyJournal Article1996
Importance of tryptophan dipoles for gramicidin channel function.Progress in Biophysics and Molecular BiologyJournal Article1996
Molecular Lego - Structure-Function Studies in Gramicidin ChannelsAbstracts of Papers of the American Chemical SocietyJournal Article1995
Gramicidin channel function does not depend on phospholipid chiralityBiochemistryJournal Article1995
Palmitoylation-Induced Conformational-Changes of Specific Side-Chains in the Gramicidin Transmembrane ChannelBiochemistryJournal Article1995
Stabilizing Effect of D-Alanine(2) in Gramicidin ChannelsBiochemistryJournal Article1995
Role of Lysine-195 in the Kmsks Sequence of Escherichia-Coli Tryptophanyl-Transfer-Rna SynthetaseFEBS LettersJournal Article1995
Voltage-Dependent Gating of an Asymmetric Gramicidin ChannelProceedings of the National Academy of Sciences of the United States of AmericaJournal Article1995
Gramicidin-a Short-Chain Phospholipid Dispersions - Chain-Length Dependence of Gramicidin Conformation and Lipid OrganizationBiochemistryJournal Article1994
Role of the Tign Sequence in Escherichia-Coli Tryptophanyl-Transfer-Rna SynthetaseBiochimica et Biophysica Acta-Protein Structure and Molecular EnzymologyJournal Article1994
Closed State of Gramicidin Channel Detected by X-Ray Inplane ScatteringBiophysical ChemistryJournal Article1994
Ambidextrous Gramicidin ChannelsBiophysical JournalJournal Article1994
Contacts That Are Good for You - Side-Chain Contacts in the Gramicidin ChannelBiophysical JournalJournal Article1994
Tryptophans and Gramicidin Channel FunctionBiophysical JournalJournal Article1994
Asymmetric Gramicidin Channels - Heterodimeric Channels with a Single F(6)Val(1) ResidueBiophysical JournalJournal Article1994
2-Dimensional Nmr Analysis of the Structure of [L-Ala1-D-Ala2] Gramicidin-a in D25 Sds MicellesBiophysical JournalJournal Article1994
Modulation of Selected Gramicidin Side-Chains by Covalent AcylationBiophysical JournalJournal Article1994
Deuterium Nmr-Studies of Leucine and Valine Side-Chains in Gramicidin ChannelsBiophysical JournalJournal Article1994
Orientations of the Tryptophan 9 and 11 Side-Chains of the Gramicidin Channel Based on Deuterium Nuclear-Magnetic-Resonance SpectroscopyBiophysical JournalJournal Article1994
A Simple and General-Method for Quantitative and Homogeneous Incorporation of Hydrophobic Peptides into Sds MicellesBiophysical JournalJournal Article1994
Helix Sense of Gramicidin Channels as a Nonlocal Function of the Primary SequenceJournal of Biological ChemistryJournal Article1994
Characterization of [L-Ala1-D-Ala2] Gramicidin-a - Stabilizing Effect of the Gly2-]D-Ala SubstitutionBiophysical JournalJournal Article1993
Lipid Chain-Length Dependence of Reciprocal Gramicidin-Lipid InteractionsBiophysical JournalJournal Article1993
Duration and Conductance of Gramicidin-a Channels with Nondipolar Position Number-1 SubstitutionsBiophysical JournalJournal Article1993
Nonconducting State of GramicidinBiophysical JournalJournal Article1993
The Tign Sequence in Escherichia-Coli Tryptophanyl-Transfer Rna-Synthetase Serves as a Class-I Aminoacyl-Transfer Rna-Synthetase High SequenceBiophysical JournalJournal Article1993
Ion Movement through a Single-Filing ChannelBiophysical JournalJournal Article1993
Energetics of Heterodimer Formation among Gramicidin Analogs with an Nh2-Terminal Addition or Deletion - Consequences of Missing a Residue at the Join in the ChannelJournal of Molecular BiologyJournal Article1993
Reversion of Escherichia-Coli-Cells Whose Growth Has Been Inhibited Due to Overproduction of Trp-Transfer-Rna SynthetaseAbstracts of Papers of the American Chemical SocietyJournal Article1992
Orientation of the Valine-1 Side-Chain of the Gramicidin Transmembrane Channel and Implications for Channel Functioning - a H-2 Nmr-StudyBiochemistryJournal Article1992
Molecular and Channel-Forming Characteristics of Gramicidin Ks - a Family of Naturally-Occurring Acylated GramicidinsBiochemistryJournal Article1992
A Dipolar Amino-Acid Substitution Induces Voltage-Dependent Transitions between 2 Stable Conductance States in Gramicidin ChannelsBiophysical JournalJournal Article1992
Models for Gramicidin ChannelsBiophysical JournalJournal Article1992
Formation of Non-Beta-6.3-Helical Gramicidin Channels between Sequence-Substituted Gramicidin AnalogsBiophysical JournalJournal Article1992
On the Supramolecular Organization of Gramicidin Channels - the Elementary Conducting Unit Is a DimerBiophysical JournalJournal Article1992
Amino-Acid Substitutions and Ion Channel Function - Model-Dependent ConclusionsBiophysical JournalJournal Article1992
Dimer Versus TetramerBiophysical JournalJournal Article1992
On the Sequence Dependence of Gramicidin Helix Handedness - Passive Role for the Central Valine ResiduesFASEB JournalJournal Article1992
Gramicidin-a Dispersions in Short-Chain Phospholipids - Effect of Lipid Chain-Length on Gramicidin ConformationFASEB JournalJournal Article1992
Nonconducting State of GramicidinFASEB JournalJournal Article1992
Determination of the Orientation of the Valine-1 Side-Chain of Gramicidin and Implications for Channel FunctioningFASEB JournalJournal Article1992
Interruption of the Gramicidin (L,D) Sequence - Channels Formed by L-Ala2-AnalogsFASEB JournalJournal Article1992
2-D Nmr Determination of the Structure of Acyl Gramicidin in D25-Sds MicellesFASEB JournalJournal Article1992
Molecular Determinants of Channel FunctionPhysiological ReviewsJournal Article1992
On the Helix Sense of Gramicidin-a Single ChannelsProteins-Structure, Function, and BioinformaticsJournal Article1992
Amino-Acid-Sequence Modulation of Gramicidin Channel Function - Effects of Tryptophan-to-Phenylalanine Substitutions on the Single-Channel Conductance and DurationBiochemistryJournal Article1991
Effect of Salt and Membrane Fluidity on Fluorophore Motions of a Gramicidin-C DerivativeBiochemistryJournal Article1991
Overexpression of Transfer Rnatrp in Escherichia-ColiFASEB JournalJournal Article1991
Distinction between Dipolar and Inductive Effects in Modulating the Conductance of Gramicidin ChannelsBiochemistryJournal Article1990
Nmr-Studies of Tyr-1 Gramicidin-ABiophysical JournalJournal Article1990
Gramicidin-a, Gramicidin-B, and Gramicidin-C Form Structurally Equivalent Ion ChannelsBiophysical JournalJournal Article1990
Gramicidin Single-Channel Properties Show No Solvent-History DependenceBiophysical JournalJournal Article1990
Voltage-Dependent Gating of Gramicidin Channels Induced by Single Amino-Acid ReplacementBiophysical JournalJournal Article1990
Cooh-Terminal Substitutions in Gramicidin Channel Affect Conductance HeterogeneityBiophysical JournalJournal Article1990
Amino-Acid-Sequence Modulation of Gramicidin Single Channel DurationsBiophysical JournalJournal Article1990
Gramicidin Channels Are Right-Handed Beta-Helical DimersBiophysical JournalJournal Article1990
Energetics of Gramicidin Hybrid Channel Formation as a Test for Structural Equivalence - Side-Chain Substitutions in the Native SequenceJournal of Molecular BiologyJournal Article1990
Kinetics of Gramicidin Channel Formation in Lipid Bilayers - Transmembrane Monomer AssociationScienceJournal Article1990
Induction of Conductance Heterogeneity in Gramicidin ChannelsBiochemistryJournal Article1989
Mechanism of Uncoupling of Oxidative-Phosphorylation by GramicidinBiochemistryJournal Article1989
Stimulation of Cation-Transport in Mitochondria by Gramicidin and Truncated DerivativesBiochemistryJournal Article1989
Fatty-Acid Components of Gramicidin-KBiophysical JournalJournal Article1988
Ti-205 Nuclear Magnetic-Resonance Determination of the Thermodynamic Parameters for the Binding of Mono-Valent Cations to Gramicidin-A and Gramicidin-CBiophysical JournalJournal Article1988
Thermodynamic Parameters for Association of the Group-I Metal-Cations with Gramicidin-ABiophysical JournalJournal Article1987
Linear Gramicidins Can Form Channels That Do Not Have the Beta-6.3 StructureBiophysical JournalJournal Article1987
On the Conductance Heterogeneity in Membrane Channels Formed by Gramicidin-a - a Cooperative StudyBiophysical JournalJournal Article1987
Amino-Acid-Sequence Alterations and Structure-Function Studies in a Membrane ChannelBiophysical JournalJournal Article1987
Free-Energy of Dimerization of Gramicidin Hybrid ChannelsJournal of Cellular BiochemistryJournal Article1987
Investigation of the Interaction between Thallous Ions and Gramicidin-a in Dimyristoylphosphatidylcholine Vesicles - a Tl-205 Nmr Equilibrium StudyBiochemistryJournal Article1986
Single-Channel Studies on Linear Gramicidins with Altered Amino-Acid Side-Chains - Effects of Altering the Polarity of the Side-Chain at Position-1 in Gramicidin-ABiophysical JournalJournal Article1986
Equilibrium Binding Constants for the Group-I Metal-Cations with Gramicidin a Determined by Competition Studies and Tl+-205 Nmr-SpectroscopyBiophysical JournalJournal Article1986
Equilibrium Binding Constants for the Group-I Metal-Cations with Gramicidin-A Determined by Competition Studies and Tl+-205 Nuclear-Magnetic-Resonance SpectroscopyBiophysical JournalJournal Article1986
Equilibrium Binding Constants for T1+ With Gramicidin-A, Gramicidin-B, and Gramicidin-C in a Lysophosphatidylcholine Environment Determined by Tl-205 Nuclear-Magnetic-Resonance SpectroscopyBiophysical JournalJournal Article1986
Structural Information from Functional Measurements - Single-Channel Studies on Gramicidin AnalogsBiophysical JournalJournal Article1986
Gramicidin-K, a New Linear Channel-Forming Gramicidin from Bacillus-BrevisBiochemistryJournal Article1985
Gramicidin-K - a New Linear Channel-Forming Gramicidin from-Bacillus BrevisBiophysical JournalJournal Article1985
On the Recovery of Cys-Containing Peptides during Peptide-Mapping by Hplc - Tryptic Peptides of Trp-Transfer Rna-Synthetase of Escherichia-ColiFEBS LettersJournal Article1985
Semisynthesis of Linear Gramicidins Using Diphenyl Phosphorazidate (Dppa)International Journal of Peptide and Protein ResearchJournal Article1985
Complexing Properties of GramicidinsMetal Ions in Biological SystemsJournal Article1985
Single-Channel Studies on Linear Gramicidins with Altered Amino-Acid-Sequences - a Comparison of Phenylalanine, Tryptophane, and Tyrosine Substitutions at Position-1 and Position-11Biophysical JournalJournal Article1984
5-a Fourier Map of Gramicidin a Phased by Deuterium-Hydrogen Solvent Difference Neutron-DiffractionBiophysical JournalJournal Article1984
Computer Building of Beta-Helical Polypeptide ModelsBiopolymersJournal Article1984
Single-Channel Studies on Linear Gramicidins with Altered Amino-Acid-SequencesHoppe-Seylers Zeitschrift für Physiologische ChemieJournal Article1984
Difference in Association of Tl(I) with Gramicidin-a and Gramicidin-B in Trifluoroethanol Determined by Tl-205 NmrBiochimica et Biophysica Acta-General SubjectsJournal Article1983
Single-Channel Studies on Modified GramicidinsBiophysical JournalJournal Article1983
Deuterium-Hydrogen Difference Neutron-Diffraction - an Approach to the Phase Problem for Single-Crystals of Ion-Free Gramicidin-ABiophysical JournalJournal Article1983
Inhibition of Trp Transfer Rna-Synthetase from Escherichia-Coli by Mesitoyl-5'-AmpFederation ProceedingsJournal Article1983
Inhibition of Escherichia-Coli Tryptophanyl Transfer-Rna Synthetase by L-Tryptophan-Chloromethyl-KetoneFederation ProceedingsJournal Article1982
Hydrogen-Deuterium Difference Neutron-Diffraction Analysis of Bound Solvent in Gramicidin a CrystalsFederation ProceedingsJournal Article1981
Resolution of Linear Gramicidins by Preparative Reversed-Phase High-Performance Liquid-ChromatographyJournal of Chromatography AJournal Article1981
Semi-Synthetic Gramicidin a Derivatives for CrystallographyAbstracts of Papers of the American Chemical SocietyJournal Article1980